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医学诊断质谱技术研究组

科研骨干

李海洋  博士  研究员

研究工作简介


中国科学院大连化学物理研究所"快速分析与检测"课题组组长。1984年毕业于郑州大学化学系;1992年在中科院大连化物所获理学博士学位,导师张存浩、沙国河院士。先后在香港大学(1995),日本分子科学研究所(1997),美国肯塔基大学(1998-2000),加拿大NRC分子科学研究所(2002),美国ORNL国家实验室(2009)等进行访问研究。

1999年入选中国科学院,2000 -2004年在中国科学院安徽光机所建立环境光化学实验室,开展大气光化学、自由基光谱学以及先进飞行时间质谱技术在大气检测中应用的研究。2003年7月起担任大化所快速分析和检测课题组组长,开展高端过程分析仪器和在线监测技术的研究。在Analytical Chemistry、Scientific Reports等国际权威杂志发表学术论文180余篇, 在新仪器研制方面申请专利近150项。

工作和教育经历

1980.08 -1984.08,郑州大学,化学专业,理学学士
1984.12--1987.08,河南安阳大学,助教
1987.09-1992.07,中科院大连化学物理研究所,物理化学专业,理学博士
1992.08—1998.02,中科院大连化学物理研究所,助理研究员
(其间:1995.02--1996.02 香港大学,博士后;1997.06--1997.12 日本国立分子科学研究所,博士后)
1998.03--2000.06,美国肯塔基大学,博士后
2000.06--2004.01,中国科学院安徽光学精密机械研究所,环境光谱学实验室副主任,研究员
2004.01-2022.04,中国科学院大连化学物理研究所,快速分离与检测课题组组长,研究员
2022.04至今,中国科学院大连化学物理研究所,质谱与快速检测研究中心主任,研究员

代表性文章

(1) Chen, C.; Chen, H.; Jiang D.; Li, M.; Huang W.; Li, H. Enhancing the sensitivity of ion mobility spectrometry using the ion enrichment effect of non-uniform electrostatic field. Sensors and Actuators B: Chemical, 2019, 295: 179-185.
(2) Hong Chen, Chuang Chen*, Wei Huang, Mei Li, Yao Xiao, Dandan Jiang, Haiyang Li*. Miniaturized Ion Mobility Spectrometer with a Dual-compression Tristate Ion Shutter for On-site Rapid Screening of Fentanyl Drug Mixtures. Analytical Chemistry. 2019
(3) Shuang Wang, Weimin Wang, Hong Li, Yuming Xing, Keyong Hou*, and Haiyang Li*. Rapid On-Site Detection of Illegal Drugs in Complex Matrix by Thermal Desorption Acetone-Assisted Photoionization Miniature Ion Trap Mass Spectrometer. Analytical Chemistry. 2019, 91 (6), 3845–3851
(4) Wang, Y.; Hua, L.; Li, Q.; Jiang, J.; Hou, K.; Wu, C.; Li, H. Direct Detection of Small n Alkanes at Sub-ppbv Level by Photoelectron-Induced O2+ Cation Chemical Ionization Mass Spectrometry at kPa Pressure. Analytical Chemistry. 2018, 90, 5398−5404.
(5) Jiang, D.; Li, E.; Zhou, Q.; Wang, X.; Li, H.; Ju, B.; Guo, L.; Liu, D.; Li, H. Online Monitoring of Intraoperative Exhaled Propofol by Acetone-Assisted Negative Photoionization Ion Mobility Spectrometry Coupled with Time-Resolved Purge Introduction. Analytical Chemistry 2018, 90, 5280−5289.
(6) Chen, C.; Chen, H.; Li H. Pushing the Resolving Power of Tyndall−Powell Gate Ion Mobility Spectrometry over 100 with No Sensitivity Loss for Multiple Ion Species. Analytical Chemistry 2017, 89, 13398−13404.
(7) Wang, Y.; Jiang, J.; Hua, L.; Hou, K.; Xie, Y.; Chen, P.; Liu, W.; Li, Q.; Wang S.; Li H. High-Pressure Photon Ionization Source for TOFMS and Its Application for On-line Breath analysis. Analytical Chemistry 2016, 88, 9047-9055.
(8) Jiang, J.; Wang, Y.; Hou, K.; Hua, L.; Chen, P.; Liu, W.; Xie, Y.; Li, H. Photoionization-Generated Dibromomethane Cation Chemical Ionization Source for Time-of-Flight Mass Spectrometry and Its Application on Sensitive Detection of Volatile Sulfur Compounds. Analytical Chemistry 2016, 88, 5028-5032.
(9) Jiang, D.; Peng, L.; Wen, M.; Zhou, Q.; Chen, C.; Wang, X.; Chen, W.; Li, H. Dopant-Assisted Positive Photoionization Ion Mobility Spectrometry Coupled with Time-Resolved Thermal Desorption for On-Site Detection of Triacetone Triperoxide and Hexamethylene Trioxide Diamine in Complex Matrices. Analytical Chemistry 2016, 88, 4391-4399.
(10) Hua, L.; Hou, K.; Chen, P.; Xie, Y.; Jiang, J.; Wang, Y.; Wang, W.; Li, H. Realization of In-Source Collision-Induced Dissociation in Single-Photon Ionization Time-of-Flight Mass Spectrometry and Its Application for Differentiation of Isobaric Compounds. Analytical Chemistry 2015, 87, 2427-2433.
(11) Chen, C.; Tabrizchi, M.; Wang, W.; Li, H. Field Switching Combined with Bradbury-Nielsen Gate for Ion Mobility Spectrometry. Analytical Chemistry 2015, 87, 7925-7930.
(12) Xie, Y.; Hua, L.; Hou, K.; Chen, P.; Zhao, W.; Chen, W.; Ju, B.; Li, H. Long-Term Real-Time Monitoring Catalytic Synthesis of Ammonia in a Microreactor by VUV-Lamp-Based Charge-Transfer Ionization Time-of-Flight Mass Spectrometry. Analytical Chemistry 2014, 86, 7681-7687.
(13) Cheng, S.; Wang, W.; Zhou, Q.; Chen, C.; Peng, L.; Hua, L.; Li, Y.; Hou, K.; Li, H. Fast Switching of CO3-(H2O)n and O2-(H2O)n Reactant Ions in Dopant-Assisted Negative Photoionization Ion Mobility Spectrometry for Explosives Detection. Analytical Chemistry 2014, 86, 2687-2693.
(14) Chen, P.; Hou, K.; Hua, L.; Xie, Y.; Zhao, W.; Chen, W.; Chen, C.; Li, H. Quasi-Trapping Chemical Ionization Source Based on a Commercial VUV Lamp for Time-of-Flight Mass Spectrometry. Analytical Chemistry 2014, 86, 1332-1336.